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Majini (a Swahili word meaning "evil spirit") are the main antagonists of Resident Evil 5, much as the Ganados were the main antagonists in RE4. Majini are unfortunate humans who have been taken over by the weaponized Las Plagas parasite developed by Wesker, making them stronger, tougher, more violent, and far less rational.

Majini encountered early in the game are roughly equivalent to the Ganados of RE4 in terms of power; later in the game, the player encounters test subjects of a "type 3" Las Plagas parasite that further increases strength and stamina and can increase the subject's height to around nine feet. The Majini with a chainsaw still has a burlap sack over his head.

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